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TREM1 (Triggering receptor expressed on the surface of myeloid cells-1) is a myeloid cell surface receptor expressed on the surface of neutrophils, monocytes, and macrophages, and is expressed in a variety of tumor microenvironments, synergizing with the classical pattern recognition receptor (PRR). Examples include the Toll-like receptor (TLR) and Nod-like receptor (NLR) families, which amplify inflammatory responses mediated by microbial components in host defense.