Analysis of UBAP1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1954-LGZ)

Introduction

Official Full Name: ubiquitin associated protein 1<br />Also known as: UAP; UBAP; NAG20; SPG80; UBAP-1<br />This gene is a member of the UBA domain family, whose members include proteins associated with the ubiquitin and ubiquitination pathways. The ubiquitin-associated domain is considered a non-covalent ubiquitin-binding domain consisting of a tight triple-helical bundle. This particular protein originates from a locus in the refinement region of chromosome 9 that occurs in nasopharyngeal carcinoma (NPC) where loss of heterozygosity occurs. Given its cytogenetic location, this UBA domain family member is being investigated as a putative mutational target in nasopharyngeal carcinoma. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.