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Official Full Name: ubiquitin specific peptidase 21<br />Also known as: USP16; USP23<br />This gene encodes a member of the C19 peptidase family, also known as ubiquitin carboxy-terminal hydrolase family 2. The encoded protein cleaves ubiquitin from ubiquitinated proteins and is recycled for intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-binding protein. The gene was once known as USP16 and USP23, but is now known as USP21. Alternative splice transcript variants of this gene have been found to encode distinct isoforms.