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Vascular endothelial growth factor receptor 3 (VEGFR-3), also known as Flt-4, is a tyrosine kinase receptor for VEGF-C and VEGF-D. This protein is involved in the formation and maintenance of lymphatic vessels in the lymphatic endothelium. High expression of VEGFR-3 can be found in lymphatic endothelial cells isolated from cancer tissues of lymphoma patients.