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Aminoglycosides are potent, broad-spectrum antibiotics that act through inhibition of protein synthesis. Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, as well as bacteremia and endocarditis. They are also used for prophylaxis, especially against endocarditis. Resistance is rare but increasing in frequency. But the major side effects of aminoglycosides are kidney injury, hearing impairment and vestibular toxicity.