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Staphylokinase (SAK; also known as staphylococcal fibrinolysin or Müller's factor) is a protein produced by Staphylococcus aureus. Staphylokinase Promotes the Establishment of Staphylococcus aureus Skin Infections While Decreasing Disease Severity. In a plasma milieu, staphylokinase is able to dissolve fibrin clots without associated fibrinogen degradation. This fibrin-specificity of staphylokinase is the result of reduced inhibition by alpha2-antiplasmin of plasmin.