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Noncoding RNA sequences, including long noncoding RNAs, small nucleolar RNAs, and untranslated mRNA regions, accomplish many of their diverse functions through direct interactions with RNA-binding proteins (RBPs).<br /><br />Protein–RNA complexes are dynamic, and the kinetics of binding and release could influence many processes, such as the ability of RNA–binding proteins to compete for binding sites, the sequential assembly of ribonucleoprotein complexes, and the ability of bound RNA to move between cellular compartments. To attain a complete and biologically relevant understanding of RNA–protein interactions, complex formation must be studied not only in equilibrated reactions, but also as a dynamic process.