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Glutamate is the most abundant excitatory neurotransmitter in your brain and central nervous system. It's needed to keep your brain functioning properly. Glutamate plays a major role in shaping learning and memory. Glutamate needs to be present at the right concentrations in the right places at the right time.
SH2 domains have been identified as 100-amino acid motifs that are included in the noncatalytic regions of signaling proteins such as src, fps, PLC-y, and u-crk. Interest in SH2 domains has been heightened in recent years with the discoveries that SH2 domains bind specifically to phosphotyrosine-containing peptides and
that many signaling pathways, from antigen stimulation to interferon transcription, operate through SH2 domain binding. Many SH2 domains recognize specific amino acid sequences surrounding phosphotyrosine (pY), as is the case for p56lck which binds to the sequence pYEEI, derived from a degenerate peptide library. Because of the clear connection between SH2 domains and mitogenic signaling pathways, there are obvious opportunities for pharmacological intervention in disease states characterized by excessive cellular proliferation.