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In humans, FcεRI controls the activation of mast cells and basophils, and participates in IgE-mediated antigen presentation. Multivalent antigens bind and crosslink IgE molecules held at the cell surface by FcεRI. Receptor aggregation induces multiple signalling pathways that control diverse effector responses. IgE binds to two types of Fc receptors, called Fc epsilon R1 (or high-affinity Fc epsilon R) and Fc epsilon R2 (or low-affinity Fc epsilon R). IgE-mediated cross-linking of FcεRI receptors induces mast cell activation and release of granule-associated mediators, biogenesis, and release of lipid mediators, as well as synthesis and release of cytokines.