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The hemagglutinin(HA) of influenza virus is a major glycoprotein and plays a crucial role in the early stage of virus infection: HA is responsible for binding of the virus to cell surface receptors, and it mediates liberation of the viral genome into the cytoplasm through membrane fusion. And Influenza virus hemagglutinin (HA) proteins bind to sialic acid residues on the surface of the host cell.