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Receptor-ligand interactions are a major class of protein-protein interactions and play an important role in many biological processes such as metabolism, neurotransmission and cellular signal transduction pathways. When a ligand binds to its respective receptor, the shape and/or activity of the ligand is altered to initiate several different types of cellular responses. Such cellular responses are vital for the proliferation, migration, survival, and differentiation of cells within all multicellular organisms.