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Herpes simplex virus (HSV) glycoprotein D (gD) is a viral envelope glycoprotein that has been studied extensively by immunological, biochemical, and genetic approaches. It is one of the essential glycoproteins for virus entry, and much evidence indicates that it functions by interacting with a cellular receptor.<br /><br />HVEM is a member of the TNFR family and acts as both ligand and receptor. As a ligand, HVEM engages the members of the Ig superfamily, BTLA and CD160. As a receptor, HVEM binds the canonical TNF-related ligands, lymphotoxin-α (LT-α) and LIGHT, both being TNF family members.