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Fragment-based drug discovery is a validated approach for the discovery of drug candidates. Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins. These compounds have a low molecular weight, making them penetrate cells easily. Small-molecule drugs can be developed from leads derived from rational drug design or isolated from natural resources. And fragment-based drug discovery (FBDD) is now a proven method for designing clinical candidates comparable with high-throughput screening (HTS) approaches.