Detection of drugs of abuse in fingerprints by Raman Spectroscopy (CAT#: STEM-ST-0028-WXH)

Introduction

Raman spectroscopy has been proved as a good complementary method for detection of drugs of abuse in fingerprints. This kind of study was done on five drugs of abuse that is codeine phosphate, cocaine hydrochloride, amphetamine sulphate, barbital and nitrazepam. Detection of these drugs was successfully achieved and clearly distinguished using their Raman spectra obtained from the substances in cyanoacrylate-fumed fingerprints (polymer is deposited on the fingerprint material for enhancing the visibility).

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Principle Applications Procedure Materials Notes Related Products

Principle

Raman Spectroscopy is a non-destructive chemical analysis technique which provides detailed information about chemical structure, phase and polymorphy, crystallinity and molecular interactions.
The principle behind Raman spectroscopy is that the monochromatic radiation is passed through the sample such that the radiation may get reflected, absorbed, or scattered. The scattered photons have a different frequency from the incident photon as the vibration and rotational property vary.

Applications

• Analysis of biocompatibility of a material.
• Analysis of nucleic acids.
• Study of interactions between drugs and cells.
• Photodynamic therapy (PDT).
• Analyzing metabolic accumulations of a substance or compounds.
• Diagnosis of disease.
• Analysis of individual cells.
• Cell sorting applications.
• Analyzing the features of biomolecules.
• Study of bone structure.

Procedure

1. Preparation of samples
2. Determine instrument parameters
3. Perform background scan
4. Test the sample
5. Data analysis

Materials

• Raman Spectrometer
• Raman Imaging Microscope

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