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The descriptions of the fluid-mosaic model led to an increased focus on understanding the lipid dynamics in biological membranes and gave rise to multiple ways of investigating these; a very popular technique is the use of synthetic membranes. Several synthetic membrane systems have been developed to understand the basic lipid physics in biological membranes. When working with synthetic membranes, the composition and behavior are better controlled, allowing for a more consistent investigation of the feasibility of analytical methods.