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Acetaminophen (APAP) is a non-opioid analgesic and antipyretic agent used to treat pain and fever. It is used as a single agent for mild to moderate pain and combined with an opioid analgesic for severe pain. Although this drug is very safe in therapeutic doses (4 g per day) for most patients, it sometimes exhibits hepatic toxicity even in these therapeutic doses, especially among population with similar type risk factors such as those encountered in cases of hepatic surgery, acute or chronic hepatopathies, chronic alcohol consumption or fasting and malnutrition. This service provides a sensitive and robust method to quantify acetaminophen and its main metabolites in urine.