Determination of Melting Point of Curcuminoid Powder by Open Capillary Method (CAT#: STEM-PPA-0071-YJL)

Introduction

Curcumin is a liposoluble compound and can be easily dissolved into organic solvent such as methanol, ethanol, and acetone. However, poor water solubility oіen limits its biomedical uses using aqueous systems. Нis observation prompted us to examine turmeric extracts as a delivery system for curcumin and to examine the possibility of turmeric extract itself as candidate agent for pharmacologic evaluation. The melting point of the curcuminoid powder was determined using open capillary method.

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds

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