Determination of Melting Point of Sulfonamide Based Transition Metal Complexes by Open Capillary Method (CAT#: STEM-PPA-0110-YJL)

Introduction

In inorganic chemistry most active research area is coordination chemistry. Recently, numbers of coordination metal complexes have been synthesized and investigated, which exhibit various biological activities. Sulpha drugs are largely in used as chemotherapeutic agents whose molecular structures contain a 4- aminobenzene sulfonamide moiety. The Sulpha drugs and their derivatives show diverse biological activities like antihypertensive agent bosentan, antibacterial, antiprotozoal, antifungal, anti-inflammatory, nonpeptidic vasopressin receptor antagonists and translation initiation inhibitors. The reaction of maleic anhydride derivatives with sulphanilamide has not been reported for metal complaxation so far. Hence, it was thought that maleic anhydride and sulphanilamide moieties can put into one molecule frame may afford good biological active compound.