Determination of Melting Point of Some New Sulfadiazine Derivatives by Capillary Method (CAT#: STEM-PPA-0116-YJL)

Introduction

The molecular structures of sulfa drugs that containing the 4- aminobenzenesulfonamide moiety play important roles as a chemotherapeutic agent. The biological activity of these drugs is thought to come from the structural similarity between sulfanilamide group and p-amino benzoic acid where the sulpha drug simulators this metabolite and blocks folic acid synthesis in bacteria, thereby causing cell death. Sulfadiazine exhibits in vitro inhibitory activity against several aerobic gram-positive and gram-negative bacteria, Sulfadiazine is one of the medication populace of barbituric acids has concern. Azirine a small heterocyclic ring system are of largest importance in theoretical, synthetic organic, bio organic and medicinal chemistry, and in particular aziridines are very useful and interesting systems as they occur in a sum of accepted and biologically lively substances.