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Determination of Melting Point of Novel Cinnamamide Deriverties by Open Capillary Method (CAT#: STEM-PPA-0108-YJL)

Introduction

Cinnamamides and its derivatives possess wide range of activities in several fields. Such as medicinal, pharmaceuticals, agricultural, biological and many other activities. In medicinal field several Cinnamamides and their derivatives are reported to show central nervous system depressant, anticonvulsant, muscle relaxant, antiallergic, antineoplastic, antitumor, anesthetic, analgesic and anti-infective activities , etc. In the agrochemical field, insecticidal, their avian repellent, herbicidal activities, and several excellent cinnamamide fungicides for example dimethomorph, fluormorph and pyrimorph, have been successfully developed. Biological screening of the synthesized compounds is most important task which decides the practical utility of compounds in various fields such as medicinal, pharmaceuticals etc. Inspire of wide range of their applications and very less attention is paid towards the synthesis of cinnamamides derivatives containing heterocyclic moiety.




Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds
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