Determination of Melting Point of 2-(aminomethyl)dicarboxylic Acids by Open Capillary Method (CAT#: STEM-PPA-0086-YJL)

Introduction

Melting point is one of the most important properties used to characterize organic compounds. The information contained in the melting point is more than just the temperature of the phase change; its value also can be related to molecular symmetry, as compounds of a high molecular symmetry generally will have high melting points. Melting thermodynamics, such as enthalpy of fusion (ΔfusH) and especially entropy of fusion (ΔfusS), can be related to disorder in the solid state.
The β2-amino acids were synthesized as homologues and isomers of common α-amino acids (or α-aminodicarboxylic acids). The α-amino acids are involved in a large number of metabolic processes, and the motivation for synthesis of these β2-amino acids was based on their biological effects and intrinsic potential as enzyme inhibitors.