Determination of Melting Point of Rifampicin by Open Capillary Method (CAT#: STEM-PPA-0074-YJL)

Introduction

Tuberculosis (TB) is one of the most common causes of morbidity and mortality in the world today. Despite all the efforts, the disease is not coming to grip. Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and rarely by other organisms of the “tuberculosis complex”. It is usually transmitted by inhalation of infected droplet nuclei which are discharged into the air when a patient with untreated sputum positive TB coughs or sneezes. Rifampicin is bactericidal to Mycobacterium tuberculosis and many other Gram positive and gram negative bacteria. The deviation from the melting point of a sample is an indication of the impurities in the sample. A Small amount of Impurity can be determined by lowering as well as the widening of the melting point range. The melting point of Rifampicin was determined by the open capillary method.