The lateral groups of the most typical and essential parts of bodilycells are based on aromatic heterocyclic, consequently, it plays an essential part in biochemical directions. As a consequence of improvement of systems useful for gathering molecules containing heterocyclic units continues to be a focus for the care of both educational and industrial communities. The 1,3-Oxazole and Imidazol units constitute useful biological active compounds. A wide ranging of biological activity, the 1,3,4-Thiadiazole and 1,3,4-oxadiazol rings along with aromatic heterocycles. The study of heterocyclic chemistry attentions especially on unsaturated products, and the majority of work and applications include unstrained 5- and 6- membered ring such as pyridine, thiophene, pyrrole and furan.