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Determination of Melting Point of Guanine Substituted Heterocyclic Derivatives by Open Capillary Method (CAT#: STEM-PPA-0112-YJL)

Introduction

The lateral groups of the most typical and essential parts of bodilycells are based on aromatic heterocyclic, consequently, it plays an essential part in biochemical directions. As a consequence of improvement of systems useful for gathering molecules containing heterocyclic units continues to be a focus for the care of both educational and industrial communities. The 1,3-Oxazole and Imidazol units constitute useful biological active compounds. A wide ranging of biological activity, the 1,3,4-Thiadiazole and 1,3,4-oxadiazol rings along with aromatic heterocycles. The study of heterocyclic chemistry attentions especially on unsaturated products, and the majority of work and applications include unstrained 5- and 6- membered ring such as pyridine, thiophene, pyrrole and furan.




Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds
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