Determination of Melting Point of Oral Floating Tablet of Cephalexin (CEF) by Open Capillary Method (CAT#: STEM-PPA-0098-YJL)

Introduction

Oral delivery of drugs is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation etc. From immediate release to site specific delivery, oral dosage forms have really progressed. Formulation of floating tablet containing cephalexin as a drug candidate, which would remain in stomach or upper part of GIT for prolonged period of time, therefore the maximum drug release is maintained at desired site. Cephalexin having good absorption in GIT, low pKa, which remain unionized in stomach for better absorption. Cephalexin is a semisynthetic cephalosporin β lactum antibiotic intended for oral administration used to treat urinary tract infections, respiratory tract infections, skin and soft tissue infections. Pharmacokinetic parameters of cephalexin such as absorption from the gastrointestinal tract, protein binding 14%, and metabolism 90% excreted unchanged in the urine, half-life is 1 hour.