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Since the dawn of humanity, natural products have been used in a traditional medicine to manage many illnesses affected on human health. Recently, many of marketed drugs have been originated directly or indirectly from these products. Also, current drug research is actively screened the possible pharmacological activities of many Ayruvedic and traditional Indian medicinal therapies. Among those being investigated, curcumin attracts a growing interest.Curcumin is the main natural polyphenol found in the rhizome of Curcuma longa (turmeric). This natural product has demonstrated a wide range of biological and pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, anti-diabetic, anti-malarial, antiprotozoal and antioxidant activities.