Determination of Melting Point of Transition Metal Complexes Derived from 2-hydroxy-n-phenyl-benzamide by Open Capillary Method (CAT#: STEM-PPA-0113-YJL)

Introduction

The role of metal chelates in all aspects of biological studies has gained considerable importance, as they provide valuable approaches to the metabolic studies, oxidative phosphorylation, transmethylation and principles of chemotherapy. Azomethines, bonding through nitrogen and oxygen or sulphur atoms to the central metal ion form an important class of biologically active ligands and provide models for metal ligand binding sites in several enzyme. Keeping those facts in view, the present ligand 2-hydroxy-N-phenylbenzamide and its transition metal complexes have been synthesized and characterized.

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds

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