Determination of Melting Point of Benzoxazinone Material by Open Capillary Method (CAT#: STEM-PPA-0064-YJL)

Introduction

In the field of medicinal chemistry, compounds which consist of Benzoxazinone moieties are of huge significance due to their pharmacological characteristics. Benzoxazinone derivates combined with aromatic ring system and heterocyclic are found to be possessing different activities such as analgesic, anti-inflammatory, antifungal, and antimicrobial. The iosteric replacements of other rings for example oxaxolo and pyrido derivates are found to be producing antimicrobial activity. The Benzoxazinone are considered as important group of secondary metabolites occurring in Ranunculaceae, acanthaceae, and Gramineae. These compounds function as defense mechanism against pests such as insects and bacteria fungi.

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds

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