Determination of Melting Point of Liposomes Containing Metformin Hydrochloride by Open Capillary Method (CAT#: STEM-PPA-0089-YJL)

Introduction

The term liposome (meaning lipid body) was derived on the basis of names of sub cellular particles like lysozome and ribosome. It is defined as a spherule/vesicle of lipid bilayers enclosing an aqueous compartment. The lipid most commonly used is phospholipids. Sphingolipids, glycolipids and sterols have also been used to prepare liposomes. Liposomes are synthetic vesicles consisting of one or morephospholipid bilayers, able to accommodate water lipid-soluble molecules. They are used as a delivery system for drugs, genes and vaccines in therapeutics.
Designing of controlled release formulation is necessary to maintain steady state plasma concentration for longer period of time and to reduce the frequency of administration. So, an attempt was made to formulate liposomal suspensions containing Metformin hydrochloride to sustain its action.