Determination of Melting Point of Pharmaceutical cocrystals of Ibuprofen by Open Capillary Method (CAT#: STEM-PPA-0092-YJL)

Introduction

Ibuprofen [(+/ -) 2 -(p- isobutylphenilpropanoic acid (CH3)2CHCH2-C6H4CH3CHCO2H] iswell known as a non-steroidal anti- inflammatory (NSAID), analgesic and antipyretic agent.It is a weakly acidic drug having high permeability through stomach because it remain99.9 %unionize in stomach (pKa of Ibuprofen- 4.43, pH of gastric fluid - 1.2). To improve dissolution of such drug ischallenging and rational. However, commercially available ibuprofen particles are needle likewith rough surfaces and show poor flowability, poor compaction behaviour and a tendency tostick to the tablet punches. To overcome these problems, a suitable size and shape ofibuprofen crystal is desirable that could be directly compressed.
Pharmaceutical cocrystals of Ibuprofen were prepared with cocrystal formers, such as oxalicacid, benzoic acid, 3-aminobenzoic acid, 4-aminobenzoic acid, urea, salicylic acid, cinnamicacid, succinic acid and citric acid, to improve drug solubility.