Determination of Melting Point of New Derivatives of 1, 3-benzoxazin-4-one by Open Capillary Method (CAT#: STEM-PPA-0083-YJL)

Introduction

Depression is a serious medical issue characterized by a variety of debilitating symptoms, such as persistent sadness and anxiety, chronic fatigue, feelings of worthlessness, disturbances in cognitive functioning and thoughts and attempts of suicide. Depression has been determined to be the leading cause of disability and the 4th leading contributor to the global burden of disease and is characterized by relapse, recurrence and chronicity. Antidepressants are the drugs used to treat depression thereby elevates mood and modifies the behavior. Half a century ago, antidepressants were discovered by serendipity. Current treatments for depression either fail to produce recovery or induce unwanted side effects. So there is still a large unmet clinical need. The main aims in the development of new antidepressants were greater efficacy, absence of side effects, lack of toxicity in over dose and earlier onset of action.