Determination of Melting Point of Novel Pyrazolyl Tetrazoles As Selective COX-2 Inhibitors by Open Capillary Method (CAT#: STEM-PPA-0106-YJL)

Introduction

Currently marketed non steroidal anti-inflammatory drugs (NSAIDs) have been associated with several side effects like gastrointestinal mucosal damage, bleeding, intolerance, renal toxicity, and hepatotoxicity. The pharmacological effects of NSAIDs occur due to inhibition of the membrane enzyme called cyclooxygenase (COX-1 and COX-2), which is involved in prostaglandin biosynthesis.
Pyrazole template is considered as an important chemical entity of various physiological significances and pharmaceutical utility. Pyrazoles have drawn a greater attention due to their wide range of therapeutic activities including anticonvulsant, antidepressant, antitumor, antimicrobial, ACE inhibitor, antiviral, anti-inflammatory, etc. The well known selective COX-2 inhibitor, Celecoxib, and non steroidal antiphlogistic drug. Lonazolac, are good examples of pyrazoles containing anti-inflammatory drugs. According to literature, tetrazole and its derivatives are known to possess antibacterial, anti-inflammatory, antifungal, cyclo-oxygenase inhibitor, hypoglycemic, and anticancer activities.