Determination of Melting Point of Halolitoralin A by Open Capillary Method (CAT#: STEM-PPA-0107-YJL)

Introduction

Antimicrobial peptides have played a crucial role in pharmaceutical research as biomedically useful agents or as lead compounds for drug development. Halolitoralins are natural cyclic peptides isolated from the bacterial strain Halobacillus litoralis YS3106 of marine origin. These cyclic congeners are associated with diverse biological activities, such as antifungal and antitumor activities. Only the minute quantities of cyclopeptides, ranging from di to hexapeptides, obtained from natural resources5 restricted researchers from investigating their biological profiles in detail. Considering the wide spectrum of bioactivities associated with these natural congeners and in order to obtain a potent bioactive compound in good yield, an attempt was made to synthesize the cyclic hexapeptide halolitoralin A (8) by a solution phase technique in a convenient and economic manner.