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According to different immunogenicity, therapeutic antibody can be divided into four stages, consisting of murine antibody, chimeric antibody, humanized antibody and fully human antibody.
Mechanisms of action of therapeutic antibodies. Neutralization: Many therapeutic antibodies utilize neutralization to block the pathophysiological function of their target molecules. In this case, antibodies bind to the ligand or receptor that is expressed on the cell surface and block the target signaling pathway.