Gut-on-a-Chip

Gut-on-a-chip is a microfluidic device that consists of a series of chambers lined with human intestinal cells to mimic the structure and function of human gastrointestinal tract in a miniature, lab-grown system. These cells are exposed to fluid flow and controlled mechanical forces to simulate the peristalsis movement of the intestines.

One of the key features of Gut-on-a-Chip is its ability to model the interactions between different cell types found in the gut, such as epithelial cells, immune cells, and gut microbiota. This allows researchers to study how these cells communicate and respond to stimuli, such as drugs, pathogens, and dietary compounds.

What We Can Do for You

Gut-on-a-chip has the potential to revolutionize drug development and personalized medicine by providing a more accurate and cost-effective platform for studying gut physiology and disease mechanisms. It can also be used to investigate the impact of diet, probiotics, and other interventions on gut health. STEMart is able to utilize gut-on-a-chip to provide the following services:

• Disease modeling: Model various gastrointestinal diseases, such as inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease to study the underlying mechanisms of these diseases and develop new treatment strategies.
• Drug screening and development: Evaluate drug absorption, metabolism, and interaction with gut microbiota, helping to identify potential drug candidates and avoid harmful side effects.
• Microbiome research: Study the interactions between the host gut cells and the microbes and investigate how these microbes affect gut function and contribute to various diseases.
• Nutritional studies: Assess the absorption of nutrients and evaluate the effects of dietary compounds on the modulation of gut microbiota.
• Toxicology testing: Assess the toxicity of environmental pollutants, food contaminants, and pharmaceutical compounds on the gut barrier.

For more information about our service related to gut-on-a-chip, please contact us.