In Vivo Pharmacodynamic Evaluation of Spontaneous Tumor Model in Old Mice (CAT#: STEM-AE-0658-LGZ)

Introduction

Mouse tumor models are very important for the study of the biological process of tumor growth and the research and development of anti-tumor therapeutic drugs. At present, common mouse tumor models include syngenic model, CDX and PDX model, but different mouse tumor models have different degrees of limitations in application and simulation of the real process of tumor. For example, the traditional transplanted tumor model (TP) is different from human tumors in several key tumor characteristics, such as vascularization, growth rate, immune infiltration, inflammation, tumor metabolism, and the influence of tumor-derived TGF-β. In contrast, animal models of spontaneous tumors are more similar to the occurrence of human tumors, but their development is slow and their growth changes are large, so they are rarely used in systematic studies.