Investigation of the toxic mechanism of difenoconazole on protein by UV-Vis Spectroscopy (CAT#: STEM-MB-0964-WXH)

Introduction

As a kind of systemic sterol demethylation inhibitor (DMI), difenoconazole has a good ability to interfere with the mycelial growth and inhibit the spore germination of pathogens that ultimately results in inhibiting fungal growth. Difenoconazole is extensively used in a wide range of crops in many countries for its good control of various fungal diseases. However most of pesticides are not completely degraded after application, their metabolites and some unchanged forms of these compounds are excreted and subsequently enter the ecosystem. Although the triazole fungicides have shorter half-lives and lower bioaccumulation than the organochlorine pesticides, possible detrimental effects on the ecosystem and human health were also existed. For this reason, knowledge of the interaction mechanisms between difenoconazole and plasma protein is of crucial importance for us to understand its possible danger to human body.