Lead Compound Discovery Service

A lead compound is a compound with pharmacological or biological activity that can be used to develop new drugs. Its chemical structure can be further modified to improve potency, selectivity and pharmacokinetic properties. The identification and discovery of lead compounds is the starting point of modern new drug research.

With the emergence of molecular-level drug screening models, screening methods and technologies have undergone fundamental changes. The development of high-throughput screening technology has greatly accelerated the search and discovery of lead compounds.

STEMart relies on advanced laboratory platforms and professional technical teams to provide a series of unique and comprehensive label-free screening methods, so as to steadily accelerate the lead compound discovery process.

Service Items

• High throughput screening
  • By using mass spectrometry techniques, ultra-high-throughput screening can be applied to a wide variety of large compound libraries. Ultra-high-throughput screening can achieve high-throughput screening of more than 100,000 samples per day. It is highly durable and can perform complete screening (primary screening) of compound libraries containing millions of substances.
• Focused screening
  • In this era of computationally driven drug development, methods that focus screening on smaller and richer compound libraries are becoming increasingly important. Mass spectrometry provides high throughput with excellent data quality and reduced redundant information.
• Fragment-based lead compound discovery
  • Low molecular weight compounds generally have lower binding affinities, so screening for these compounds requires the highest sensitivity. STEMart offers a range of advanced and high-sensitivity instruments for fragment-based screening using techniques such as SPR, NMR, mass spectrometry, X-ray crystallography and more.

For more information about our lead compound discovery services, please contact us.