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Macrophages are differentiated from circulating bone marrow-derived monocytes. The main role of macrophages is to remove cellular debris and destroy invading pathogens. Liver macrophages play an important role in the study of fibrosis, hepatitis, liver obesity diseases and liver transplantation. Liver macrophages are a good model to study the role of macrophages under normal physiological and pathological conditions.
Microglia are resident macrophages of the central nervous system, they participate in the process of maintaining brain homeostasis, and play a key role in human brain development and physiological processes during life and aging.