Recombinant Human GITR Ligand Protein, Seafrom (CAT#: STEM-CT-0149-ZJF)

The Recombinant Human GITR Ligand Protein manufactured by Seafrom is suitable for immune cell activation and regulation.
Tumor Necrosis Factor Ligand Superfamily Member 18 (TNFSF18), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL or GITR Ligand) and Activation-Inducible TNF-Related Ligand (AITRL), belongs to the tumor necrosis factor family. It is highly expressed in various tissues such as the small intestine, ovary, testis, kidney, and endothelial cells. TNFSF18/GITRL levels are up-regulated after stimulation by bacterial lipopolysaccharides (LPS).
TNFSF18/GITRL functions as a costimulator, reducing the threshold for T-cell activation and promoting T-cell proliferation. It plays a crucial role in the interactions between activated T-lymphocytes and endothelial cells. Additionally, TNFSF18/GITR Ligand is involved in mediating the activation of NF-kappa-B, a transcription factor that regulates various cellular processes.
The freeze-dried (lyophilized) form of the protein can be stored at 4℃ for up to 24 months. Once reconstituted, the liquid can be stored at -20℃ for 6-12 months, with precautions taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: TNFSF18, AITRL, TL6, hGITRL
Protein Sequence: The DNA sequence encodes human GITR Ligand (GenBank: AAD22634.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human GITR Ligand protein contains 359 amino acids, with a predicted theoretical molecular weight of 41.2 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized human GITR (His tag) at 1 μg/mL (100 μL/well) can bind to GITR Ligand (Fc tag) in a linear range of 5-20 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

Recombinant Human PD-1 Protein (Fc), Seafrom
Recombinant Human CD138 Protein, Seafrom
Recombinant Human GITR Protein, Seafrom
Recombinant Human TIGIT Protein, Seafrom