The Recombinant Human OX40 Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses. Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as ACT35 antigen, OX40 ligand receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, or simply OX40, is a protein that contains four TNFR-Cys repeats. TNFRSF4 acts as a receptor for TNFSF4 (OX40L/GP34) and is capable of interacting with signaling proteins like TRAF2, TRAF3, and TRAF5. The lyophilized product can be stored at 4°C for 24 months. After reconstitution, the liquid can be stored at -20°C for 6-12 months, but avoid repeated freeze-thaw cycles.
Specification
Expression Host: Human HEK293 cells Source: Human Synonyms: TNFRSF4, CD134, OX40L receptor, ACT35, TXGP1L Protein Sequence: The DNA sequence encodes human OX40 (NCBI Reference Sequence: NP_003318.1), expressed with a His tag at the C-terminus. Molecular Weight: Recombinant human OX40 protein consists of 189 amino acids, with a predicted theoretical molecular weight of 21.8 kD. Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis. Endotoxin: <0.1 EU/μg Biological Activity: The linear range for binding of human OX40 (His tag) at 1μg/mL (100μL/well) to human OX40 Ligand (Fc tag) is 1-10 ng/mL. Purification Method: Chromatographic purification Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.