Study of sequence preference in drug binding to DNA by Linear dichroism (LD) (CAT#: STEM-ST-0119-WXH)

Introduction

Compounds which bind to DNA with high affinity can influence gene expression and, subsequently, affect cell proliferation and differentiation. Furthermore, such compounds may exhibit antiviral and/or antitumoral activities. Using natural antibiotics as ‘lead compounds’, it is possible to design and synthesize novel antitumour agents which possess enhanced affinity toward the DNA molecule.

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Principle Applications Materials

Principle

Linear dichroism (LD) or diattenuation is the difference between absorption of light polarized parallel and polarized perpendicular to an orientation axis. It is the property of a material whose transmittance depends on the orientation of linearly polarized light incident upon it. LD measurements are based on the interaction between matter and light and thus are a form of electromagnetic spectroscopy.

Applications

Study the functionality and structure of molecules.

Materials

• Polarizer
• Absorbance spectrometer

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