Study of sequence preference in drug binding to DNA by Linear dichroism (LD) (CAT#: STEM-ST-0119-WXH)

Introduction

Compounds which bind to DNA with high affinity can influence gene expression and, subsequently, affect cell proliferation and differentiation. Furthermore, such compounds may exhibit antiviral and/or antitumoral activities. Using natural antibiotics as ‘lead compounds’, it is possible to design and synthesize novel antitumour agents which possess enhanced affinity toward the DNA molecule.

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Principle Applications Procedure Materials Notes Related Products

Principle

Linear dichroism (LD) or diattenuation is the difference between absorption of light polarized parallel and polarized perpendicular to an orientation axis. It is the property of a material whose transmittance depends on the orientation of linearly polarized light incident upon it. LD measurements are based on the interaction between matter and light and thus are a form of electromagnetic spectroscopy.

Applications

Study the functionality and structure of molecules.

Materials

• Polarizer
• Absorbance spectrometer

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