Study of the effect of ANG II on PVN neurons by Patch clamp (CAT#: STEM-PET-0060-WXH)

Introduction

Neurons of the hypothalamic paraventricular nucleus (PVN) are key controllers of sympathetic nerve activity and receive input from angiotensin II (ANG II)–containing neurons in the forebrain.
The paraventricular nucleus of the hypothalamus (PVN) has emerged as one of the most important autonomic control centers in the brain, with neurons playing essential roles in controlling stress, metabolism, growth, reproduction, immune, and other more traditional autonomic functions (gastrointestinal, renal and cardiovascular).
Ang-II stimulates neurotransmission in the PVN via AT1R, leading to increases in arterial BP and renal sympathetic nerve activity.