Study of the interaction between DNA and porphyrins by Circular dichroism (CD) (CAT#: STEM-MB-0610-WXH)

Introduction

Porphyrin, any of a class of water-soluble, nitrogenous biological pigments (biochromes), derivatives of which include the hemoproteins (porphyrins combined with metals and protein).
DNA is an obvious target for drug intervention since disruption of its structure clearly will have significant biological implications. Studies on the interaction of cationic porphyrins (as a ligand) and their derivatives with DNA have received interest. Particularly, porphyrins have been reported from the viewpoint of their use in photodynamic therapy of cancer cells, DNA cleavers and as drugs to treat some infectious diseases such as AIDS.