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It is considered that the sea buckthorn genus includes 15 species and subspecies, but only 4 of them have found wide application in practice: the Chinese subspecies (sinensis), the European (rhamnoides), Central Asian (turkestanica) and Siberian (mongolica). Fruits of sea buckthorn have a complex chemical composition, represented by such groups of biologically active substances (BAS), as flavonoids, amino acids, organic acids, tannins, water- and fat-soluble vitamins, polysaccharides, easily digestible sugars. In this service, the study of the profile of biologically active substances (free organic acids and sugars, as well as free and related amino acids) of sea buckthorn fruits of various varieties is carried out by capillary electrophoresis.