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Botulinum neurotoxins (BoNTs) are bacterial proteins that cause the life-threatening disease botulism, and are considered as among the highest-risk threat agents for bioterrorism (the "Class A agents"). Seven antigenically-distinct BoNT serotypes (designated A to G) are produced by several species of anaerobic Clostridia: C. botulinum, C butyricum, C. baratii, and C. argentinense. Botulism is a disease with four distinct, naturally-occurring syndromes: foodborne, wound, infant botulism, and adult intestinal toxemia. Inhalational botulism can result from aerosolization of the toxin. All BoNT serotypes act via similar mechanisms on their target nerve cell: initial binding of the C-terminal portion of the heavy chain through ganglioside and protein receptors on the presynaptic cell surface, followed by internalization into and translocation within the nerve ending by the N-terminal portion of the heavy chain. Each BoNT serotype has specific action site. Serotypes B, D, F, and G cleave vesicle associated membrane protein (VAMP or synaptobrevin).