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HP1 was originally described as a dominant suppressor of position-effect variegation in Drosophila melanogaster. The mammalian HP1 protein family consists of three members: HP1α, β and γ. As the main reader of repressive histone marks H3K9me2/3, HP1 is a key factor in heterochromatin formation and maintenance. And HP1γ is predominantly found in euchromatin, within the transcribed regions of active genes. HP1γ plays important roles in developmental processes and cell fate decisions. For instance, depletion of HP1γ in mESCs results in endodermal and neuronal differentiation defects. HP1γ can regulat transcription during differentiation.