Analysis Biomolecular Interactions of P-selectin and PSGL-1 to rhRod by BLI (CAT#: STEM-MB-0108-CJ)

Introduction

Leukocyte (WBC) capture on both platelets and vascular endothelium plays a key role in the initiation of acute inflammation. This early process is mediated through the interactions between adhesion molecules found on WBC, namely P-selectin glycoprotein ligand-1 (PSGL-1) and the β2-integrins (CD11a/CD18 [LFA-1] and CD11b/CD18 [Mac-1]) to those found on platelets and endothelial cells (e.g., P-selectin, GP1bα, E-selectin, and ICAM-1). These interactions will lead to WBC crawling and eventual transendothelial migration. Normally, inflammation is important in the maintenance of health, such as in infection and wound healing. But inflammation can also be pathologic, leading to tissue injury and organ dysfunction in both directly affected as well as distant sites, such as secondary acute lung injury and sepsis-associated liver injury.