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Vascular Endothelial Growth Factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. VEGF165 functions as a dimer and promotes the formation of VEGFR2 dimers resulting in activation of the kinase domains via the phosphorylation of its tyrosine residues. Robust tyrosine phosphorylation results in the activation of angiogenic signaling pathways. VA2 and VA22 are RNA aptamers.