Analysis Biomolecular Interactions of Lrp to Target Regions of the P.aeruginosa Chromosome by BLI (CAT#: STEM-MB-0231-CJ)

Introduction

Pseudomonas aeruginosa, a Gram-negative bacillus native to soil and aqueous environment, is capable of inhabiting a wide variety of environments. This bacteria has been shown to attach and grow in biofilms on PVC pipes, persist in distilled water, live on the surface of human skin or cause infection within many body tissues. It is an opportunistic pathogen of burn victims, immunocompromised individuals, and cystic fibrosis (CF) patients. Since the treatment of P. aeruginosa infections with antibiotics became common practice, antibiotic resistant strains have developed and pose serious complications in successful treatment. P. aeruginosa is particularly challenging for CF patients because it can inhabit the lungs (often as a co-infection with Staphylococcus aureus) and form a biofilm in the sticky mucus that cannot be penetrated by therapeutic antibiotics. Once their respiratory pathway is colonized, the biofilm is difficult to remove from these patients. The vast majority of CF patients will die from these infections.