Analysis of 4-1BB/TNFRSF9/CD137 by ELISA (CAT#: STEM-MB-1563-LGZ)

Introduction

4-1BB, also known as TNFRSF9 or CD137, is a receptor of the tumor necrosis factor superfamily. The human 4-1BB gene encodes a type I transmembrane protein consisting of 255 amino acids, including 17 amino acid N-terminal signal peptide, 169 amino acid extracellular region, 27 amino acid transmembrane region, and 42 amino acid extracellular region. Recombinant Human Soluble 4-1BB is a 167-amino acid polypeptide (17.7kDa) including cystine-rich TNFr-like extracellular domain of 4-1BB. 4-1BB is mainly expressed on the surface of various T cells, but also in B cells, monocytes and a variety of transformed cell lines. This protein contributes to clonal proliferation, survival and T cell development. It also induces peripheral monocyte proliferation, enhances T cell apoptosis induced by TCR/CD3 activation, and modulates CD28 co-stimulation to promote Th1 cell response. Expression of this protein is induced by lymphocyte activation. The TRAF transfer protein binds to this protein and transduces the signal that activates NF-κB. It is also involved in the development of inflammation in high-fat foodborne metabolic syndrome.